Title

Towards a better understanding of medicinal uses of the brown seaweed genus Sargassum in traditional Chinese medicine: a phytochemical and pharmacological review

Document Type

Article

Publication details

Liu, L, Heinrich, M, Myers, SP & Dworjanyn, SA 2012, 'Towards a better understanding of medicinal uses of the brown seaweed genus Sargassum in traditional Chinese medicine: a phytochemical and pharmacological review', Journal of Ethnopharmacology, vol. 142, pp. 591-619.

The publisher's version of this article is available at

http://dx.doi.org/10.1016/j.jep.2012.05.046

Peer Reviewed

Peer-Reviewed

Abstract

Ethnopharmacological relevance

Sargassumspp., a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including thyroid disease (e.g. goitre).

Aims of the review

To assess the scientific evidence for therapeutic claims made for Sargassum spp. in TCM and to identify future research needs.

Background and methods

A systematic search for the use of Sargassum in classical TCM books was conducted and linked to a search for modern phytochemical and pharmacological data on Sargassum spp. retrieved from PubMed, Web of Knowledge, SciFinder Scholar and CNKI (in Chinese).

Results and discussion

>The therapeutic effects of Sargassum spp. are scientifically plausible and may be explained partially by key in vivo and in vitro pharmacological activities of Sargassum, such as anticancer, anti-inflammatory, antibacterial and antiviral activities. Although the mechanism of actions is still not clear, the pharmacological activities could be mainly attributed to the major biologically active metabolites, meroterpenoids, phlorotanins and fucoidans. The contribution of iodine in Sargassum for treating thyroid related diseases seem to have been over estimated.

Conclusions

The bioactive compounds in Sargassum spp. appear to play a role as immunomodulators and could be useful in the treatment of thyroid related diseases such as Hashimoto's thyroiditis. Further research is required to determine both the preventative and therapeutic role of Sargassum spp. in thyroid health.