Title

Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini

Document Type

Article

Publication details

Beattie, KD, Thompson, D, Tiralongo, E, Ratkowsky, D, May, TW & Gill, M 2011, 'Austrocolorone B and austrocolorin B1, cytotoxic anthracenone dimers from the Tasmanian mushroom Cortinarius vinosipes Gasparini', Tetrahedron Letters, vol. 52, no. 42, pp. 5448-5451.

Published version available from:

http://dx.doi.org/10.1016/j.tetlet.2011.08.015

Peer Reviewed

Peer-Reviewed

Abstract

The yellow dihydroanthracenone dimer, austrocolorin B1 and the unique violet-red 1,4-anthraquinone dimer, austrocolorone B, were isolated from the Tasmanian mushroom Cortinariusvinosipes and their structures and stereochemistry were determined from spectroscopic data. Austrocolorin B1 and austrocolorone B were found to exhibit potent cytotoxic activity in vitro against the murine lymphoblast (P388D1) cell line with IC50 values in the range 10–31 μg/mL.