Title

A new anti-inflammatory glucoside from Ficus racemosa L.

Document Type

Article

Publication details

Li, RW, Leach, DN, Myers, SP, Lin, GD, Leach, GJ & Waterman, PG 2004, Planta Medica, vol. 70, no. 5, pp. 421-426.

Published version available from:

http://dx.doi.org/10.1055/s-2004-818969

Peer Reviewed

Peer-Reviewed

Abstract

Bioassay-guided fractionation of the ethanol extract of Ficus racemosa resulted in the identification of a new compound (rel)-4,6-dihydroxy-5-[3-methyl-(E)-propenoic acid-3-yl]-7-β-glucopyranosyl-{2α,3β-dihydrobenzofuran}-(3,2:b)-[4α,5β-dihydroxy-6α-hydroxymethyltetrahydropyran] (racemosic acid). Racemosic acid showed potent inhibitory activity against COX-1 and 5-LOX in vitro with IC50 values of 90 and 18 μM, respectively. Racemosic acid also demonstrated a strong antioxidant activity to scavenge ABTS free radical cations with an IC50 value of 19 μM. In addition, cytotoxic effects of the extracts of F. racemosa were investigated in vitro using the ATP-based luminescence assay and results showed no cytotoxicity on the cell lines skin fibroblasts (1BR3), human Caucasian hepatocyte carcinoma (Hep G2) and human Caucasian promyelocytic leukaemia (HL-60). Bergenin was also isolated from the same active fraction.