Title

A novel sulfur-containing diterpenoid from Fritillaria anhuiensis

Document Type

Article

Publication details

Shou, QY, Tan, Q, & Shen, ZW 2009, 'A novel sulfur-containing diterpenoid from Fritillaria anhuiensis', Tetrahedron Letters, vol. 50, no. 28, pp. 4185-4187.

Publisher's version of article available at http://dx.doi.org/10.1016/j.tetlet.2009.05.002

Peer Reviewed

Peer-Reviewed

Abstract

Two novel diterpenoids were isolated from the bulbs of Fritillaria anhuiensis S. C. Chen and S. E. Yin. Compound 1 was the first diterpenoid containing a sulfonyl group isolated from nature. Compound 2 was a novel kaurane-type diterpenoid. Their structures were determined by extensive spectroscopic analysis (IR, MS, NMR, and X-ray diffraction). Compound 1 significantly attenuated nitric oxide (NO) production of a macrophage cell line of Raw 264.7 cells stimulated with IFN-γ.