Title

Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities

Document Type

Article

Publication details

Shou, QY, Tan, Q & Shen, ZW 2009, 'Hirtellanines A and B, a pair of isomeric isoflavonoid derivatives from Campylotropis hirtella and their immunosuppressive activities', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 13, pp. 3389-3391.

Bioorganic and Medicinal Chemistry Letters home page available at http://www.sciencedirect.com/science/journal/0960894X

Publisher's version of article available at http://dx.doi.org/10.1016/j.bmcl.2009.05.043

Peer Reviewed

Peer-Reviewed

Abstract

A pair of isomeric isoflavonoid derivatives, Hirtellanines A (1) and B (2), has been isolated from the roots of Campylotropis hirtella (Franch.) Schindl. and their structures were elucidated on the basis of spectroscopic methods, with special emphasis on 1D and 2D NMR techniques. The in vitro assay showed that Hirtellanine A had strong B lymphocyte suppression activity (IC50: 0.06 μM) and T lymphocyte suppression activity (IC50: 0.92 μM). Hirtellanine B showed moderate B lymphocyte suppression activity (IC50: 3.00 μM) and T lymphocyte suppression activity (IC50: 9.55 μM). Due to the potent immunosuppressive activities and lower cytotoxicity, Hirtellanine A could be a promising lead towards novel immunosuppressive agents.