F-κB modulators from Valeriana officinalis
Jacobo-Herrera, NJ, Vartiainen, N, Bremner, P, Gibbons, S, Koistinaho, J & Heinrich, M 2006, 'F-κB modulators from Valeriana officinalis', Phytotherapy Research, vol. 20, no. 10, pp. 917-919.
Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy. This study reports that the EtOAc extract of the underground parts of V. officinalis showed inhibitory activity against NF-ÎºB at 100 Î¼/mL in the IL-6/Luc assay on HeLa cells and provided protection against excitotoxicity in primary brain cell cultures at micromolar concentrations. Bioassay-guided fractionation of the EtOAc extract led to the isolation of three known sesquiterpenes: acetylvalerenolic acid (1), valerenal (2) and valerenic acid (3), 1 and 3 were active as inhibitors of NF-ÎºB at a concentration of 100 Î¼g/mL. Acetylvalerenolic acid (1) reduced NF-ÎºB activity to 4%, whereas valerenic acid (3) reduced NF-ÎºB activity to 25%.