Title

In vitro evaluation of effects of two ghanaian plants relevant to wound healing

Document Type

Article

Publication details

Mensah, A Y, Houghton, P J, Dickson, R A, Fleischer, T C, Heinrich, M, & Bremner, P 2006, 'In vitro evaluation of effects of two ghanaian plants relevant to wound healing', Phytotherapy Research, vol. 20, no. 11, pp. 941-944.

The definitive version is available at www3.interscience.wiley.com,

http://dx.doi.org/10.1002/ptr.1978

Peer Reviewed

Peer-Reviewed

Abstract

Commelina diffusa and Spathodea campanulata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 µg/mL and 10 µg/mL. The extracts showed no inhibition of NF-κB at 100 µg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents.