Hypericin as a non-antioxidant inhibitor of NF-ÎºB
Bork, PM, Bacher, S, Schmitz, ML, Kaspers, U & Heinrich, M 1999, 'Hypericin as a non-antioxidant inhibitor of NF-ÎºB', Planta Medica, vol. 65, no. 4, pp. 297-300.
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NF-ÎºB is a transcription factor involved in immune and inflammatory responses. Here we show that micromolar concentrations of hypericin inhibited the PMA- and TNF-Î±-induced activation of NF-ÎºB in HeLa and TC10 cells, respectively. In contrast, NF-ÎºB activated by H2O2 was not influenced by hypericin, indicating a pathway-specificity of hypericin. Hyperforin and a Hypericum perforatum extract standardised on 0.15% hypericin and 5% hyperforin were not active at pharmacologically relevant concentrations. The PMA/TNF-Î±-induced transcription of a reporter gene, which is under the control of the NF-ÎºB-dependent IL-6 promoter, was strongly reduced by preincubation with hypericin.