Title

Phytochemical and biological investigation of Begonia heracleifolia

Document Type

Article

Publication details

Frei, B, Heinrich, M, Herrmann, D, Orjala, JE, Schmitt, J & Sticher, O 1998, 'Phytochemical and biological investigation of Begonia heracleifolia', Planta Medica, vol. 64, no. 4, pp. 385-386.

Published version available from:

http://dx.doi.org/10.1055/s-2006-957460

Peer Reviewed

Peer-Reviewed

Abstract

From the rhizomes of Begonia heracleifolia six known cucurbitacins (1-6) were isolated. Based on spectral data (1D and 2D 1H-, 13C-NMR, ESI- and CI- MS) the structures were established as cucurbitacin B (1), cucurbitacin D (2), 23,24-dihydrocucurbitacin D (3), 23,24-dihydrocucurbitacin F (4), 2-O-β- glucopyranosyl-cucurbitacin B (5), and 2-O-β-glucopyranosyl-cucurbitacin D (6). Four of them (3-6) were so far not reported as constituents of Begonia spp. Varyingly strong antiproliferative activity towards tumor and immune cells was observed for three compounds (1-3), due to different structural features.