Pheophorbide A from Solanum diflorum interferes with NF-κB activation
Heinrich, M, Bork, PM, Schmitz, ML, Rimpler, H, Frei, B & Sticher, O 2001, 'Pheophorbide A from Solanum diflorum interferes with NF-κB activation', Planta Medica, vol. 67, no. 2, pp. 156-157.
Published version available from:
Continuing our search for biogenic NF-ÎºB inhibitors we investigated Solanum diflorum, used by the Istmo Sierra Zapotec Indians of Mexico in the treatment of inflammatory skin conditions. It became obvious very early that the active substance seems to be a degradation product of chlorophyll. Pheophorbide A was identified as one of the key compounds responsible for the NF-ÎºB inhibitory activity. The compound interferes with NF-ÎºB activation, was cytotoxic if exposed to light, but devoid of any cytotoxic activity in the dark.