Title

Antifungal constituents of Melicope borbonica

Document Type

Article

Publication details

Simonsen, HT, Adsersen, A, Bremner, P, Heinrich, M, Smitt, UW & Jaroszewski, JW 2004, 'Antifungal constituents of Melicope borbonica', Phytotherapy Research, vol. 18, no. 7, pp. 542-545.

Published version available from:

http://dx.doi.org/10.1002/ptr.1482

Peer Reviewed

Peer-Reviewed

Abstract

Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6- methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (α-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antfinflammatory activity in vitro. No alkaloids were detected.