Title

Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)

Document Type

Article

Publication details

Gibbons, S, Leimkugel, J, Oluwatuyi, M & Heinrich, M 2003, 'Activity of Zanthoxylum clava-herculis extracts against multi-drug resistant methicillin-resistant Staphylococcus aureus (mdr-MRSA)', Phytotherapy Research, vol. 17, no. 3, pp. 274-275.

Publishers version available at:

http://dx.doi.org/10.1002/ptr.1112

Peer Reviewed

Peer-Reviewed

Abstract

In a continuing search for compounds with antibiotic activity against methicillin-resistant Staphylococcus aureus (MRSA) possessing multidrug efflux systems, we have demonstrated activity associated with extracts from Southern prickly ash bark, Zanthoxylum clava-herculis. Bioassay-guided isolation of an alkaloid extract led to the characterization of the benzo[c]phenanthridine alkaloid chelerythrine as the major active principle. This compound exhibited potent activity against strains of MRSA, which were highly resistant to clinically useful antibiotics via multidrug efflux mechanisms.