Document Type

Thesis

Publication details

Wang, Y 2016, 'Effects and molecular mechanisms of acute and intermittent exposure to hypoxia environment and endurance exercise on glucose homeostasis and insulin resistance in obese mice with type 2 diabetes', PhD thesis, Southern Cross University, Lismore, NSW.

Copyright Y Wang 2016

Abstract

This thesis examined the effects of exposure to moderate hypoxia (15%O2 in hypoxia chamber) on fasting blood glucose and insulin level, Akt activity and GLUT4 translocation in skeletal muscle, and pancreatic β-cell function, in C57BL/6J mice with high-fat diet induced type 2 diabetes. The results demonstrated that one hour exposure had an acute effect in reducing fasting blood glucose, that may be manifested via an insulin-independent pathway; four weeks intermittent exposure (one hour per day) normalized fasting blood glucose and resulted in improvements in the insulin-dependent signalling pathway and islets β-cell function; and exercise in hypoxia had no additive effects.

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