Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot
Barwick, AL, Tessier, JW, Janse de Jonge, X, Ivers, JR & Chuter, VH 2016, 'Peripheral sensory neuropathy is associated with altered postocclusive reactive hyperemia in the diabetic foot', BMJ Open Diabetes Research & Care, vol. 4, no. 1.
Objective This study examined whether the presence of peripheral sensory neuropathy or cardiac autonomic deficits is associated with postocclusive reactive hyperemia (reflective of microvascular function) in the diabetic foot.
Research design and methods 99 participants with type 2 diabetes were recruited into this cross-sectional study. The presence of peripheral sensory neuropathy was determined with standard clinical tests and cardiac autonomic function was assessed with heart rate variation testing. Postocclusive reactive hyperemia was measured with laser Doppler in the hallux. Multiple hierarchical regression was performed to examine relationships between neuropathy and the peak perfusion following occlusion and the time to reach this peak.
ResultsPeripheral sensory neuropathy predicted 22% of the variance in time to peak following occlusion (p
Conclusions This study found an association between the presence of peripheral sensory neuropathy in people with diabetes and altered microvascular reactivity in the lower limb.