A randomized controlled trial of whole body vibration on markers of bone turnover in postmenopausal women
Turner, S, Torode, M, Climstein, M, Naughton, G, Greene, D, Baker, MK & Fiatarone Singh, MA 2011, 'A randomized controlled trial of whole body vibration on markers of bone turnover in postmenopausal women', Journal of Osteoporosis, vol. 2011, art. 710387.
Purpose. To examine the effects of two doses of low-frequency (12 Hz), low-magnitude (0.3 g), whole body vibration on markers of bone formation and resorption in postmenopausal women. Methods. Women were recruited and randomized into a sham vibration control group, one time per week vibration group (1×/week), or three times per week vibration group (3×/week). Vibration exposure consisted of 20 minutes of intermittent vibration for the 1×/week and 3×/week groups, and sham vibration (Results. Forty-six women (59.8 ± 6.2 years, median 7.3 years since menopause) were enrolled. NTx/Cr was significantly reduced (34.6%) in the 3×/wk vibration group but not in the 1×/wk vibration group compared with sham control ( ) group. No effect of time or group allocation was observed on the bone formation marker ALP ( ). Conclusion. We have shown for the first time that low-frequency, low-magnitude vibration 3×/week for eight weeks in postmenopausal women results in a significant reduction in NTx/Cr, a marker of bone resorption, when compared with sham vibration exposure.