High expression of MHC I in the tibialis anterior muscle of a paraplegic patient
Hartkopp, A, Andersen, JL, Harridge, SDR, Crone, C, Gruschy-Knudsen, T, Kjaer, M, Masao, M, Ratkevicius, A, Quistorff, B, Zhou, S & Biering-Sorensen, F 1999, 'High expression of MHC I in the tibialis anterior muscle of a paraplegic patient', Muscle & Nerve, vol. 22, no. 12, pp. 1731-1737.
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A long-term paraplegic man presented exclusively (>99%) myosin heavy chain I (MHC I) in the tibialis anterior muscle (TA). This was coupled to a slow speed of contraction, a high resistance to fatigue, and a rapid resynthesis of phosphocreatine after an electrically evoked fatiguing contraction when compared with the TA muscles of 9 other paraplegic individuals. In contrast, the MHC composition of his vastus lateralis, gastrocnemius, and soleus muscles was that expected of a muscle from a spinal cord injured individual. This information may be of clinical importance in terms of the expected morphological and functional adaptations of skeletal muscle to different types of electrical stimulation therapy