Phenylpropanoid NF-kB inhibitors from Bupleurum fruticosum

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Brernner, P, Tang, S, Birkmayer, H, Fiebich, BL, Muñoz, E, Marquez, N, Rivera, D & Heinrich, M 2004, 'Phenylpropanoid NF-kB inhibitors from Bupleurum fruticosum', Planta Medica, vol. 70, no. 10, pp. 914-918.

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Two phenylpropanoids from Bupleurum fruticosum (Apiaceae/ Umbelliferae) were shown to inhibit the transcriptional activity induced by PMA or TNFα of an NF-κB-controlled reporter gene. Western blot experiments indicated that the phenylpropanoids did not prevent 1κBα degradation, suggesting that their molecular target is at a post-1KB degradation level. Both compounds prevented cytokine (IL-1, IL-6, TNF, IL-8) release and prostaglandin E2 synthesis.