Phytochemical and biological investigation of Begonia heracleifolia
Frei, B, Heinrich, M, Herrmann, D, Orjala, JE, Schmitt, J & Sticher, O 1998, 'Phytochemical and biological investigation of Begonia heracleifolia', Planta Medica, vol. 64, no. 4, pp. 385-386.
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From the rhizomes of Begonia heracleifolia six known cucurbitacins (1-6) were isolated. Based on spectral data (1D and 2D 1H-, 13C-NMR, ESI- and CI- MS) the structures were established as cucurbitacin B (1), cucurbitacin D (2), 23,24-dihydrocucurbitacin D (3), 23,24-dihydrocucurbitacin F (4), 2-O-Î²- glucopyranosyl-cucurbitacin B (5), and 2-O-Î²-glucopyranosyl-cucurbitacin D (6). Four of them (3-6) were so far not reported as constituents of Begonia spp. Varyingly strong antiproliferative activity towards tumor and immune cells was observed for three compounds (1-3), due to different structural features.